Biomarkers

Rapid expansion of Treg cells protects from collateral colitis following a viral trigger

Rapid expansion of Treg cells protects from collateral colitis following a viral trigger

Regulatory T (Treg) cells are important for the induction and maintenance of peripheral tolerance; therefore, they are key in preventing excessive immune responses and autoimmunity and are responsible for maintaining homeostasis. Treg cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), including

Faecal Calprotectin as a biomarker in Crohn’s disease

Faecal Calprotectin as a biomarker in Crohn’s disease

Crohn’s disease is an inflammatory bowel disease, which causes inflammation of your digestive tract with symptoms such as abdominal pain, fever, diarrhoea, and weight loss. It is a recurrent disease interspersed with periods of remission. Control of the inflammatory process allows for the healing of the intestinal mucosa, which leads to lower recurrence and less complication. Identification of markers that can safely distinguish between remission and increased endoscopic disease activity, including mild activity, is important. Colonoscopy is the standard method, however, it is invasive. The ideal markers for the assessment of inflammatory activity in Crohn’s disease patients should be non-invasive, accurate and low-cost.